Project

Osteoarthritis. The RESTORATION project will develop functionally gradient bioceramic composite plugs for osteochondral applications, with the following features:

  • Matched mechanical properties within the plug for both bone and cartilage.
  • Deliverable where possible through minimally invasive surgical techniques, and offering immediate stability, in order that the large majority of treatments are "day case."
  • Able to be augmented by cells, proteins, growth factors, and pharmaceuticals, as appropriate to the clinical application.
  • Controlled resorption appropriate to the medical condition.

 

Vertebroplasty and Kyphoplasty. The RESTORATION project will develop a new generation of vertebral cements with appropriate biological, mechanical and rheological properties:

  • The paste should be easily injectable with a working time (that includes mixing and injection) compatible with surgical procedures (around 8-12 minutes) during which time the paste should maintain an appropriate viscosity for injection and cavity filling whilst avoiding cement extravasation into the surrounding tissues.
  • After the injection has completed, the cement should have a setting time of around 15-20 minutes, in order to enable rapid recovery and rehabilitation of the patient.
  • The hardened cement should have strength and stiffness similar to those of a healthy vertebral body and should be not only osteoconductive but also osteoinductive, so that it can stimulate in-vivo bone regeneration, establishing a strong bond with the surrounding bone.

 

Maxillofacial Fracture Fixation.Within RESTORATION project will be developed new bioceramic composites which:

  • Will posses sufficient stiffness and strength to protect and support the broken bone.
  • Will dissolve non-toxically within 24 months of placement, so that a controlled re-exposure to the mechanical environment will be provided to the healing bone, stimulating normal bone remodelling.
  • Can be manufactured to the patient’s anatomy, meaning that the surgeon will no longer be required to manipulate the plates so that proper bone alignment is achieved.
  • Can be attached, using adhesives we will develop in the project, to the bone-ends without the need for screws, and thus reducing the risk of secondary infection.

 

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